Interleukin-1 in Cerebral Ischemia.
نویسندگان
چکیده
منابع مشابه
INTERNATIONAL SYMPOSIUM Interleukin-1 in Cerebral Ischemia
During the past several years, it has become increasingly apparent that interleukin-1 (IL-1), particularly IL-1ƒÀ plays an important role in brain injury during ischemia. Studies from various laboratories have shown that IL-1ƒÀ mRNA and IL-1ƒÀ protein are synthesized early in ischemia and that the injection of IL-1ƒÀ into ischemic brain enhances edema formation. The most direct evidence that IL...
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The interleukin-1 receptor antagonist (IL-1RA) is a potential stroke treatment candidate. Intranasal delivery is a novel method thereby a therapeutic protein can be penetrated into the brain parenchyma by bypassing the blood-brain barrier. Thus, this study tested whether intranasal IL-1RA can provide neuroprotection and brain penetration in transient cerebral ischemia. In male Sprague-Dawley ra...
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Interleukin-6 (IL-6) is a neurotrophic cytokine expressed in both neurons and glia. The present study shows that cerebral ischemia produced by permanent occlusion of the middle cerebral artery (MCAO) produces a dramatic increase in IL-6 bioactivity in the ischemic hemisphere within 2 hours of MCAO (167 +/- 55 IU versus sham: 50 +/- 35 IU), with further increases at 8 hours (3,456 +/- 1,162 IU) ...
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ژورنال
عنوان ژورنال: The Keio Journal of Medicine
سال: 1996
ISSN: 1880-1293,0022-9717
DOI: 10.2302/kjm.45.230